{"id":321,"date":"2017-08-12T16:42:34","date_gmt":"2017-08-12T12:12:34","guid":{"rendered":"https:\/\/eqlimdanesh.com\/fa\/?p=321"},"modified":"2019-05-04T11:15:07","modified_gmt":"2019-05-04T06:45:07","slug":"while-not-essential-for-normal-thrombosis-and-hemostasis-plateletderived-vwf-fosters-ischemic-stroke-injury-in-mice","status":"publish","type":"post","link":"https:\/\/eqlimdanesh.com\/fa\/1396\/05\/21\/while-not-essential-for-normal-thrombosis-and-hemostasis-plateletderived-vwf-fosters-ischemic-stroke-injury-in-mice\/","title":{"rendered":"While not essential for normal thrombosis and hemostasis, plateletderived VWF fosters ischemic stroke injury in mice"},"content":{"rendered":"<p style=\"text-align: justify;\"><a href=\"https:\/\/eqlimdanesh.com\/fa\/wp-content\/uploads\/2017\/08\/13.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-322\" src=\"https:\/\/eqlimdanesh.com\/fa\/wp-content\/uploads\/2017\/08\/13-300x190.png\" alt=\"\u062b\u0628\u062a \u062c\u0631\u06cc\u0627\u0646 \u062e\u0648\u0646 \u0628\u0647 \u0648\u0633\u06cc\u0644\u0647 \u0641\u0644\u0648\u0645\u062a\u0631 \u062a\u0631\u0646\u0633\u0648\u0646\u06cc\u06a9\" width=\"300\" height=\"190\" srcset=\"https:\/\/eqlimdanesh.com\/fa\/wp-content\/uploads\/2017\/08\/13-300x190.png 300w, https:\/\/eqlimdanesh.com\/fa\/wp-content\/uploads\/2017\/08\/13-231x146.png 231w, https:\/\/eqlimdanesh.com\/fa\/wp-content\/uploads\/2017\/08\/13-50x32.png 50w, https:\/\/eqlimdanesh.com\/fa\/wp-content\/uploads\/2017\/08\/13-118x75.png 118w, https:\/\/eqlimdanesh.com\/fa\/wp-content\/uploads\/2017\/08\/13.png 690w\" sizes=\"auto, (max-width:767px) 300px, 300px\" \/><\/a><br \/>\n<strong>\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646:<\/strong> Sebastien Verhenne\u060c\u00a0Frederik Denorme\u060c\u00a0Sarah Libbrecht\u060c\u00a0Aline Vandenbulcke\u060c Inge Pareyn\u060c\u00a0Hans Deckmyn\u060c\u00a0\u00a0Antoon Lambrecht\u060c\u00a0Bernhard Nieswandt\u060c\u00a0Christoph Kleinschnitz\u060c\u00a0Karen Vanhoorelbeke\u060c\u00a0Simon F. De Meyer<\/p>\n<p style=\"text-align: justify;\"><strong>\u062a\u062c\u0647\u06cc\u0632\u0627\u062a \u0628\u0647 \u06a9\u0627\u0631 \u0631\u0641\u062a\u0647 \u062f\u0631 \u0627\u06cc\u0646 \u0645\u0642\u0627\u0644\u0647:<\/strong>\u00a0\u0631\u06cc\u06a9\u0648\u0631\u062f\u0631 \u06f8 \u06a9\u0627\u0646\u0627\u0644\u0647 (PowerLab)\u060c \u0641\u0644\u0648\u0645\u062a\u0631 \u062a\u0631\u0646\u0633\u0648\u0646\u06cc\u06a9 (Transonic Flowmeter) \u0648 \u0646\u0631\u0645 \u0627\u0641\u0632\u0627\u0631 \u0644\u0628 \u0686\u0627\u0631\u062a \u06f8 (LabChart 8)<\/p>\n<p style=\"text-align: justify;\"><strong>\u0686\u06a9\u06cc\u062f\u0647:<\/strong> \u0639\u0627\u0645\u0644 \u0641\u0648\u0646 \u0648\u06cc\u0644\u0628\u0631\u0627\u0646\u062f Von Willebrand factor \u06cc\u06a9\u06cc \u0627\u0632 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u0647\u0627\u06cc \u0641\u0627\u0632 \u062d\u0627\u062f \u0627\u0633\u062a \u06a9\u0647 \u062f\u0631 \u0647\u0645\u0648\u0633\u062a\u0627\u0632 \u062e\u0648\u0646\u06cc \u0646\u0642\u0634 \u0645\u0647\u0645\u06cc \u062f\u0627\u0631\u062f. \u0627\u06cc\u0646 \u0645\u0637\u0627\u0644\u0639\u0647 \u0628\u0631\u0627\u06cc \u0634\u0641\u0627\u0641 \u0633\u0627\u0632\u06cc \u0633\u0647\u0645 \u067e\u0644\u0627\u06a9\u062a \u0647\u0627\u06cc VWF \u062f\u0631 \u0647\u0645\u0627\u0633\u062a\u0648\u0632 \u0648\u062a\u0631\u0645\u0628\u0648\u0632 \u0627\u0646\u062c\u0627\u0645 \u0634\u062f \u0648 \u0645\u0646\u062c\u0631 \u0628\u0647 \u0627\u06cc\u0646 \u0646\u062a\u06cc\u062c\u0647 \u06af\u06cc\u0631\u06cc \u0634\u062f \u06a9\u0647 \u0639\u0644\u06cc \u0631\u063a\u0645 \u0627\u06cc\u0646\u06a9\u0647 VWF \u0646\u0642\u0634 \u062e\u06cc\u0644\u06cc \u062d\u06cc\u0627\u062a\u06cc \u062f\u0631 \u0647\u0645\u0627\u0633\u062a\u0648\u0632 \u0648 \u062a\u0631\u0648\u0645\u0628\u0648\u0632 \u0634\u0631\u06cc\u0627\u0646\u06cc \u0646\u062f\u0627\u0631\u0646\u062f\u060c \u0648\u0644\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc \u0647\u0627\u06cc thrombo-inflammatory \u0646\u0638\u06cc\u0631 \u0633\u06a9\u062a\u0647 \u0631\u0627 \u062a\u0648\u0633\u0637 \u06cc\u06a9 \u0645\u06a9\u0627\u0646\u06cc\u0632\u0645 \u0648\u0627\u0628\u0633\u062a\u0647 \u0628\u0647 GPIb \u062a\u0634\u062f\u06cc\u062f \u0645\u06cc\u200c\u06a9\u0646\u0646\u062f. \u0628\u0647 \u0639\u0628\u0627\u0631\u062a \u062f\u06cc\u06af\u0631 \u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642 \u0646\u0634\u0627\u0646 \u062f\u0627\u062f \u06a9\u0647 \u0646\u0642\u0634 \u0639\u0645\u062f\u0647 VWF \u00a0\u062f\u0631 \u0627\u06cc\u0633\u06a9\u0645\u06cc \u0645\u063a\u0632 \u0627\u0633\u062a\u060c \u0646\u0647 \u062f\u0631 \u062a\u0631\u0645\u0628\u0648\u0632 \u0648 \u0647\u0645\u0627\u0633\u062a\u0648\u0632\u0647\u0627\u06cc \u0645\u0639\u0645\u0648\u0644\u06cc. \u062f\u0631 \u0637\u0648\u0644 \u0627\u06cc\u0646 \u062a\u062d\u0642\u06cc\u0642 \u0628\u0631\u0627\u06cc \u062b\u0628\u062a \u0648 \u0622\u0646\u0627\u0644\u06cc\u0632 \u0648 \u0646\u0645\u0627\u06cc\u0634 \u062c\u0631\u06cc\u0627\u0646\u200c\u0647\u0627 \u0631\u06cc\u06a9\u0648\u0631\u062f\u0631 \u06f8 \u06a9\u0627\u0646\u0627\u0644\u0647 \u067e\u0627\u0648\u0631\u0644\u0628 \u060c \u0641\u0644\u0648\u0645\u062a\u0631 \u062a\u0631\u0646\u0633\u0648\u0646\u06cc\u06a9 \u0648 \u0646\u0631\u0645 \u0627\u0641\u0632\u0627\u0631 \u0644\u0628 \u0686\u0627\u0631\u062a \u06f8 \u0627\u0631\u0627\u0626\u0647 \u0634\u062f\u0647 \u062a\u0648\u0633\u0637 \u06a9\u0645\u067e\u0627\u0646\u06cc ADInstruments \u0628\u0647 \u06a9\u0627\u0631 \u0631\u0641\u062a\u0647 \u0627\u0633\u062a.<\/p>\n<p style=\"direction: ltr; text-align: justify;\"><strong>ABSTRACT:<\/strong>\u00a0Von Willebrand factor (VWF) is a key hemostatic protein synthesized in both endothelial cells and megakaryocytes. Megakaryocyte-derived VWF is stored in \u03b1-granules of platelets and is enriched in hyperactive \u2018ultra-large\u2019 VWF multimers. To\u00a0elucidate the specific contribution of platelet VWF in hemostasis and thrombosis we performed crossed bone marrow transplantations between C57BL\/6J and Vwf1- mice to generate chimeric mice. Chimeric mice specifically lacking platelet VWF showed normal tail bleeding and carotid artery thrombosis, similar to wild type mice.<\/p>\n<p style=\"direction: ltr; text-align: justify;\">Chimeric mice with VWF present only in platelets were not able to support normal thrombosis and hemostasis.However, using a mouse model of transient middle cerebral artery occlusion, we observed that cerebral infarct sizes and fibrin(ogen)\u00a0deposition in chimeric mice with only platelet VWF were significantly increased compared with Vwf1- mice (p &lt; 0.01). Blocking of the platelet VWF-GPIb interaction abrogated this platelet VWF-mediated injury. These data suggest that whereas platelet-derived VWF does not play a crucial role in hemostasis and arterial thrombosis, it aggravates thrombo-inflammatory diseases such as stroke via a GPIbdependent mechanism.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646: Sebastien Verhenne\u060c\u00a0Frederik Denorme\u060c\u00a0Sarah Libbrecht\u060c\u00a0Aline Vandenbulcke\u060c Inge Pareyn\u060c\u00a0Hans Deckmyn\u060c\u00a0\u00a0Antoon Lambrecht\u060c\u00a0Bernhard Nieswandt\u060c\u00a0Christoph Kleinschnitz\u060c\u00a0Karen Vanhoorelbeke\u060c\u00a0Simon F. De Meyer \u062a\u062c\u0647\u06cc\u0632\u0627\u062a \u0628\u0647 \u06a9\u0627\u0631 \u0631\u0641\u062a\u0647 \u062f\u0631 \u0627\u06cc\u0646 \u0645\u0642\u0627\u0644\u0647:\u00a0\u0631\u06cc\u06a9\u0648\u0631\u062f\u0631 \u06f8 \u06a9\u0627\u0646\u0627\u0644\u0647 (PowerLab)\u060c<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":2,"featured_media":679,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[1,3],"tags":[],"class_list":["post-321","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1","category-3"],"_links":{"self":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts\/321","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/comments?post=321"}],"version-history":[{"count":1,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts\/321\/revisions"}],"predecessor-version":[{"id":680,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts\/321\/revisions\/680"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/media\/679"}],"wp:attachment":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/media?parent=321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/categories?post=321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/tags?post=321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}