{"id":330,"date":"2017-08-26T16:32:59","date_gmt":"2017-08-26T12:02:59","guid":{"rendered":"https:\/\/eqlimdanesh.com\/fa\/?p=330"},"modified":"2019-05-04T11:13:08","modified_gmt":"2019-05-04T06:43:08","slug":"digitoxin-improves-cardiovascular-autonomic-control-in-rats-with-heart-failure","status":"publish","type":"post","link":"https:\/\/eqlimdanesh.com\/fa\/1396\/06\/04\/digitoxin-improves-cardiovascular-autonomic-control-in-rats-with-heart-failure\/","title":{"rendered":"Digitoxin improves cardiovascular autonomic control in rats with heart failure"},"content":{"rendered":"

\"\u062b\u0628\u062a<\/a>\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646:<\/strong>\u00a0N\u00fabia Mantovan Fardin\u060c Ednei Luiz Antonio\u060c Jairo Augusto Silva Montemor\u060c Glaucia Luciano da Veiga, Paulo Jos\u00e9 Ferreira Tucci\u060c and Ruy R. Campos<\/p>\n

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ABSTRACT:<\/strong> The effects of chronic treatment with digitoxin on arterial baroreceptor sensitivity for heart rate (HR) and renal sympathetic nerve activity (rSNA) control, cardiopulmonary reflex, and autonomic HR control in an animal model of heart failure (HF) were evaluated. Wistar rats were treated with digitoxin, which was administered in their daily feed (1 mg\/kg per day) for 60 days. The following 3 experimental groups were evaluated: sham, HF, and HF treated with digitoxin (HF + DIG). Weobserved an increase in rSNA in the HF group (190 \u00b1 \u06f2\u06f9 pps, n = 5) compared with the sham group (98 \u00b1 \u06f1\u06f4 pps, n = 5). Digitoxin treatment prevented an increase in rSNA (98 \u00b1 \u06f1\u06f4 pps, n = 7). Therefore, arterial baroreceptor sensitivity was decreased in the HF group (\u2212\u06f1\u066b\u06f2\u06f4 \u00b1 \u06f0\u066b\u06f0\u06f7 bpm\/mm Hg, n = 8) compared with the sham group (\u2212\u06f2\u066b\u06f2\u06f7 \u00b1 \u06f0\u066b\u06f2\u06f3 bpm\/mm Hg, n = 6). Digitoxin did not alter arterial baroreceptor sensitivity in the HF + DIG group. Finally, the HF group showed an increased low frequency band (LFb: 23\u00b1\u06f5ms2, n = 8) and a decreased high frequency band (HFb: 77\u00b1\u06f5ms2, n = 8) compared with the sham group (LFb: 14\u00b1\u06f3ms2; HFb: 86\u00b1\u06f3ms2, n = 9); the HF+DIG group exhibited normalized parameters (LFb: 15 \u00b1 \u06f3 ms2; HFb: 85 \u00b1 \u06f3 ms2, n = 9). In conclusion, the benefits of decreasing rSNA are not directly related to improvements in peripheral cardiovascular reflexes; such occurrences are due in part to changes in the central nuclei of the brain responsible for autonomic cardiovascular control.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u0646\u0648\u06cc\u0633\u0646\u062f\u06af\u0627\u0646:\u00a0N\u00fabia Mantovan Fardin\u060c Ednei Luiz Antonio\u060c Jairo Augusto Silva Montemor\u060c Glaucia Luciano da Veiga, Paulo Jos\u00e9 Ferreira Tucci\u060c and Ruy R. Campos \u062a\u062c\u0647\u06cc\u0632\u0627\u062a \u0628\u0647 \u06a9\u0627\u0631 \u0631\u0641\u062a\u0647 [\u2026]<\/span><\/p>\n","protected":false},"author":2,"featured_media":332,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-330","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3"],"_links":{"self":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts\/330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/comments?post=330"}],"version-history":[{"count":1,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts\/330\/revisions"}],"predecessor-version":[{"id":678,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/posts\/330\/revisions\/678"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/media\/332"}],"wp:attachment":[{"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/media?parent=330"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/categories?post=330"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/eqlimdanesh.com\/fa\/wp-json\/wp\/v2\/tags?post=330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}